I write to organise ideas before they become projects. Some pieces stay in my notebook; the ones that survive land here as essays and occasionally as adapted versions on my LinkedIn page. I broadly group my writing, for the time being, into three major cluster: Diagnostics Sovereignty, Precision Diagnostics, and a more broad category of Systems and Futures.
Published on linkedin on June 17th 1. Not enough evidence! When we first embarked on developing Hepatopredict, our idea was very clear: create a biomarker-based test that could reliably inform clinical decisions about liver transplantation in patients with hepatocellular carcinoma (HCC). In our minds, the pathway was straightforward: demonstrate a strong correlation with clinical outcomes,…
Published on MedEdgeMEA on May 31th Introduction: A New Frontier for Liver Transplantation Precision medicine has transformed fields like oncology and cardiology, but liver transplantation has been left behind. Despite being a domain where decisions often mean life or death, the field still relies on outdated clinical scoring systems. But this is changing. The tools…
By José Pereira Leal To the memory of Gordon Hisashi Sato (1927–2017), Scientist extraordinaire who inspired me, and many others, to imagine new rivers through the desert. Like many of his generation who witnessed the horrors of World War II, he dedicated his science and life to the service of humanity Image created with ChatGPT…
This reflection was heavily reliant on sourcing information and testing arguments with my favourite AI agent: Perplexity.AI. The ideas, interpretations, and conclusions are mine. The estimates on impact (e.g., life-years gained, cost savings) are approximations and should be taken with a grain of salt. Finally, I did my best to make sure no ‘source hallucinations’…
this was published as an article on Linkedin and copied here. As an entrepreneur in precision medicine, I keep worrying about where can my AI-powered, precision liver medicine agenda truly find a home? It’s not just a strategic exercise-though the availability of investment, the spirit of innovation in medical communities, regulatory frameworks, the appetite for…
I’ve followed Abu Dhabi Health Week from afar, and I find myself still thinking about the energy and optimism that surrounded the conversations on precision medicine and longevity. There’s something exhilarating about seeing the future of healthcare come to be—AI, genomics, new therapeutics, all promising to help us live longer, healthier lives. It’s hard not…
This post was motivated by my experiences advising startups, participating in acceleration programs, and working with academic research groups. Over the years, I’ve seen the challenges of translating biomarker discoveries into impactful diagnostic products, and I hope to share some lessons learned to help others navigate this complex but rewarding journey. Note on AI usage:…
The virtual space is now flooded with people labeling themselves with the hashtag #speaksabout and #keynotespeaker. Everybody is an expert seeking to share views, experience, expertise, even if these don’t amount to much. There are a plethora of books out there teaching you the secrets to becoming a “Highly Paid Expert” (actual title of one…
Opinion published (in Portuguese) on the national newspaper Diário de Notícias where I defend the need for a scale up strategy for Portuga. A consistent, bi-partisan effort to support entrepreneurship is steadily resulting in an abundance of start ups; now we need to help them go global: Venha daí uma estratégia de ‘Scale up’ para…
I presented the development of HepatoPredict and our experience of translating discoveries on biomarkers into clinically relevant ready to use products at the meeting Precision Medicine in Oncology In Porto. Thank you Nuno value for the invitation.