II have been a scientist for as long as I can remember. Thirty years of working on biological problems – from evolutionary cell biology and computational genomics to liquid biopsy and precision oncology diagnostics – have shaped how I think about everything else I build.
My scientific work is not a chapter I closed when I became an entrepreneur. It is the foundation the other work stands on. The credibility to walk into a clinical institution in Doha or a VC meeting in Barcelona comes from the same place as the 67 publications and h-index of 39: from having spent years doing the work, understanding what the data actually says, and knowing where the science ends and the assumption begins.
As of April 2026, my work has reached 9,500+ citations and an h-index of 39. My Google Scholar profile is here.
Scientific publications indexed on PubMed
, 2025. Hepatocellular Carcinoma Transplant Criteria Show Poor Negative Predictive Value: A Systematic Review and Meta-Analysis. J Pers Med 15.
, 2025. EsoDetect: computational validation and algorithm development of a novel diagnostic and prognostic tool for dysplasia in Barrett's esophagus. PeerJ 13:e19613
, 2025. HepatoPredict Accurately Selects Hepatocellular Carcinoma Patients for Liver Transplantation Regardless of Tumor Heterogeneity. Cancers (Basel) 17.
, 2024. Analytical validation and algorithm improvement of HepatoPredict kit to assess hepatocellular carcinoma prognosis before a liver transplantation. Pract Lab Med 39:e00365
, 2023. BRCA1 VUS: A functional analysis to differentiate pathogenic from benign variants identified in clinical diagnostic panels for breast cancer. Mol Med Rep 28.
, 2022. A Gene Expression Signature to Select Hepatocellular Carcinoma Patients for Liver Transplantation. Ann Surg 276(5):868-874
, 2022. Impact of Beer and Nonalcoholic Beer Consumption on the Gut Microbiota: A Randomized, Double-Blind, Controlled Trial. J Agric Food Chem 70(41):13062-13070
, 2022. DNA methylation fingerprint of hepatocellular carcinoma from tissue and liquid biopsies. Sci Rep 12(1):11512
, 2021. Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Severity in COVID-19 Patients. Front Microbiol 12:705020
, 2021. A Pilot Study on the Metabolic Impact of Mediterranean Diet in Type 2 Diabetes: Is Gut Microbiota the Key? Nutrients 13.
, 2020. A novel cyanobacterial geosmin producer, revising GeoA distribution and dispersion patterns in Bacteria. Sci Rep 10(1):8679
, 2019. Pericentrin-mediated SAS-6 recruitment promotes centriole assembly. Elife 8.
, 2019. Disulfiram, an alcohol dependence therapy, can inhibit the in vitro growth of Francisella tularensis. Int J Antimicrob Agents 54(1):85-88
, 2019. Diversity and Composition of Pelagic Prokaryotic and Protist Communities in a Thin Arctic Sea-Ice Regime. Microb Ecol 78(2):388-408
, 2018. Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis. J Cell Biol 217(7):2353-2363
, 2018. Microbial Diversity and Toxin Risk in Tropical Freshwater Reservoirs of Cape Verde. Toxins (Basel) 10.
, 2018. Collective electrical oscillations of a diatom population induced by dark stress. Sci Rep 8(1):5484
, 2018. Genetic Competence Drives Genome Diversity in Bacillus subtilis. Genome Biol Evol 10(1):108-124
, 2017. Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells. Nat Commun 8:15237
, 2017. Rabifier2: an improved bioinformatic classifier of Rab GTPases. Bioinformatics 33(4):568-570
, 2017. Does Hypoxic Response Mediate Primary Resistance to Sunitinib in Untreated Locally Advanced Breast Cancer? Curr Cancer Drug Targets 17(1):62-73
, 2016. RAG Recombinase as a Selective Pressure for Genome Evolution. Genome Biol Evol 8(11):3364-3376
, 2016. CYR61 and TAZ Upregulation and Focal Epithelial to Mesenchymal Transition May Be Early Predictors of Barrett's Esophagus Malignant Progression. PLoS One 11(9):e0161967
, 2016. Are There Rab GTPases in Archaea? Mol Biol Evol 33(7):1833-42
, 2015. Gene Tree Affects Inference of Sites Under Selection by the Branch-Site Test of Positive Selection. Evol Bioinform Online 11(Suppl 2):11-7
, 2015. Coiled-coil length: Size does matter. Proteins 83(12):2162-9
, 2015. Staphylococcus aureus Survives with a Minimal Peptidoglycan Synthesis Machine but Sacrifices Virulence and Antibiotic Resistance. PLoS Pathog 11(5):e1004891
, 2015. Rethinking the Niche of Upper-Atmosphere Bacteria: Draft Genome Sequences of Bacillus aryabhattai C765 and Bacillus aerophilus C772, Isolated from Rice Fields. Genome Announc 3.
, 2015. Bioinformatic approaches to identifying and classifying Rab proteins. Methods Mol Biol 1298:17-28
, 2015. Evolutionary patterns in coiled-coils. Genome Biol Evol 7(2):545-56
, 2014. Evolutionary cell biology: two origins, one objective. Proc Natl Acad Sci U S A 111(48):16990-4
, 2014. Hope for GWAS: relevant risk genes uncovered from GWAS statistical noise. Int J Mol Sci 15(10):17601-21
, 2014. A comprehensive assessment of the transcriptome of cork oak (Quercus suber) through EST sequencing. BMC Genomics 15(1):371
, 2014. Bioinformatics projects supporting life-sciences learning in high schools. PLoS Comput Biol 10(1):e1003404
, 2013. inTB - a data integration platform for molecular and clinical epidemiological analysis of tuberculosis. BMC Bioinformatics 14:264
, 2013. SNP typing reveals similarity in Mycobacterium tuberculosis genetic diversity between Portugal and Northeast Brazil. Infect Genet Evol 18:238-46
, 2013. Aurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindle. Open Biol 3(3):120185
, 2013. Genome of a Gut Strain of Bacillus subtilis. Genome Announc 1.
, 2013. A genomic signature and the identification of new sporulation genes. J Bacteriol 195(9):2101-15
, 2013. Evolution of intracellular compartmentalization. Biochem J 449(2):319-31
, 2012. The superfamily of heme-copper oxygen reductases: types and evolutionary considerations. Biochim Biophys Acta 1817(4):629-37
, 2011. Thousands of rab GTPases for the cell biologist. PLoS Comput Biol 7(10):e1002217
, 2011. Mechanisms underlying the dual-mode regulation of microtubule dynamics by Kip3/kinesin-8. Mol Cell 43(5):751-63
, 2011. Evolution: Tracing the origins of centrioles, cilia, and flagella. J Cell Biol 194(2):165-75
, 2011. A bioinformatics classifier and database for heme-copper oxygen reductases. PLoS One 6(4):e19117
, 2011. Loss of genetic redundancy in reductive genome evolution. PLoS Comput Biol 7(2):e1001082
, 2010. Stepwise evolution of the centriole-assembly pathway. J Cell Sci 123(Pt 9):1414-26
, 2009. Single choroideremia gene in nonmammalian vertebrates explains early embryonic lethality of the zebrafish model of choroideremia. Invest Ophthalmol Vis Sci 50(6):3009-16
, 2008. Evolution and dynamics of protein interactions and networks. Curr Opin Struct Biol 18(3):349-57
, 2008. The Ypt/Rab family and the evolution of trafficking in fungi. Traffic 9(1):27-38
, 2007. Multiple domain insertions and losses in the evolution of the Rab prenylation complex. BMC Evol Biol 7:140
, 2007. Evolution of protein complexes by duplication of homomeric interactions. Genome Biol 8(4):R51
, 2006. 3D complex: a structural classification of protein complexes. PLoS Comput Biol 2(11):e155
, 2006. The origins and evolution of functional modules: lessons from protein complexes. Philos Trans R Soc Lond B Biol Sci 361(1467):507-17
, 2005. The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway. Nat Struct Mol Biol 12(9):763-71
, 2005. Comparative genomics of trypanosomatid parasitic protozoa. Science 309(5733):404-9
, 2005. Novel specificities emerge by stepwise duplication of functional modules. Genome Res 15(4):552-9
, 2005. The relationship between domain duplication and recombination. J Mol Biol 346(1):355-65
, 2005. An exponential core in the heart of the yeast protein interaction network. Mol Biol Evol 22(3):421-5
, 2004. Functional evolution of the yeast protein interaction network. Mol Biol Evol 21(7):1171-6
, 2004. Detection of functional modules from protein interaction networks. Proteins 54(1):49-57
, 2003. Genome evolution reveals biochemical networks and functional modules. Proc Natl Acad Sci U S A 100(26):15428-33
, 2003. Classification schemes for protein structure and function. Nat Rev Genet 4(7):508-19
, 2003. Beyond 100 genomes. Genome Biol 4(5):402
, 2003. Structural determinants of Rab and Rab Escort Protein interaction: Rab family motifs define a conserved binding surface. Biochem Biophys Res Commun 301(1):92-7
, 2002. Analysis and preparation of stable complexes between Rab GTPases, Rab escort protein, and Rab geranylgeranyl transferase. Methods Mol Biol 189:157-65
, 2001. Evolution of the Rab family of small GTP-binding proteins. J Mol Biol 313(4):889-901
, 2001. Prenylation of Rab GTPases: molecular mechanisms and involvement in genetic disease. FEBS Lett 498(2-3):197-200
, 2000. The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily. J Mol Biol 301(4):1077-87
Publication list retrieved from NCBI using ImpactPubs
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