Ideas

Innovation & Translation

How promising science becomes an evidence-backed product or venture that survives contact with clinical practice, regulation, markets and scale.

Questions

  1. How do we turn scientific insight into a reliable and actionable product that addresses a real medical need?
  2. How should technical, clinical and market uncertainty be reduced together through validation, regulation, reimbursement, business-model development and early adoption?
  3. What forms of funding and patient capital can sustain long validation cycles while companies build the capabilities, teams and commercial traction required to scale?

Places represented

Geographic perspectives within this idea territory.

Selected writing

A curated route into the central arguments, rather than a chronological dump.

From Promising to Proven: Lessons from the Validation Trenches of Biomarker Development

Published on linkedin on June 17th 1. Not enough evidence! When we first embarked on developing Hepatopredict, our idea was very clear: create a biomarker-based test that could reliably inform clinical decisions about liver transplantation in patients with hepatocellular carcinoma (HCC). In our minds, the pathway was straightforward: demonstrate a strong correlation with clinical outcomes,…

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Rebuilding the Case for Diagnostics Investment (2/2): A Framework for Investors

Published on LinkedIn on Nov 20th In Part 1/2 (https://www.linkedin.com/pulse/rebuilding-case-diagnostics-investment-12-reflections-pereira-leal-swvbf), I discussed why diagnostics face a systematic funding gap despite being essential infrastructure for precision medicine, and outlined five strategic directions for entrepreneurs building diagnostic companies. Those reflections emerged from building Ophiomics and follow from the reflection I’ve been making for my book, Precision Diagnostics:…

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On Translating Bioinformatics for the economy

Presenting at the Ciência 2010, a national science showcasing initiative by FCT and other governmental agencies, about “TRANSLATING BIOINFORMATICS RESEARCH FOR HEALTH, BIOTECH AND THE ECONOMY“, at the Bioinformatics and Computational Biology session.

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In defense of a Scale Up Portugal program

Opinion published (in Portuguese) on the national newspaper Diário de Notícias where I defend the need for a scale up strategy for Portuga. A consistent, bi-partisan effort to support entrepreneurship is steadily resulting in an abundance of start ups; now we need to help them go global: Venha daí uma estratégia de ‘Scale up’ para…

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All related writing

21 articles