I am the Principal investigator of the Computational Genomics Laboratory at the Instituto Gulbenkian de Ciência in Oeiras, Portugal.
In my group we study evolutionary cell biology (EvoCell) of intracellular compartmentalisation. Evocell is a scientific area at the intersection of classical evolutionary theory and molecular cell biology, and where the advent of omics technologies allow our bioinformatics approaches to be very relevant. Our main areas of research are:
We study these problems in long evolutionary times, at the million to billion of year scale. More recently, we have used Cancer as a model to study evolution in short time frames - years, rather than millions of years.
From 2007 to 2014 I was the Head of the Bioinformatics unit of the Instituto Gulbenkian de Ciência, a research support facility that supports the work of researchers at the Instituto Gulbenkian de Ciência, and other Institutions in the Oeira Campus, Including ITQB and IBET. The Bioinformatics unit provides support in the areas of biological data analysis, next generation sequencing, data warehousing, etc.